Hepatitis C: Is Regression of Advanced Fibrosis Possible after Treatment?

Liver cirrhosis represents a severe complication for hepatitis C patients. Patients with cirrhosis require immediate treatment; a sustained virological response has been demonstrated to reduce the probability of complications and to improve the prognosis. The optimal outcome of treatment is regression, which in many cases is difficult to achieve due to histological changes. Nevertheless, cirrhosis regression has been reported in >50% of patients treated with antiviral drugs who were assessed by biopsy both before and after treatment. Similar results were obtained when transient elastography was used to estimate fibrosis stage. However, more studies with longer follow-up periods are necessary to confirm whether the decrease in liver stiffness resulting from a sustained virological response to a direct-acting antiviral is correlated with improved clinical outcomes.